ZIA CP010126 10598 (ZIA) | |||
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Title | Ghana Breast Cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Garcia-Closas, Montserrat | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $576,632 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (50.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Behavioral and Social Science (50.0%) |
Breast (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Background: There currently exists scant information on breast cancer that occurs among African women, although data suggest that, like African-American women, the cancers that develop among African women tend to occur at younger ages and have worse prognostic features than those occurring among American Caucasians. Given that breast cancer incidence rates are increasing in many African nations and that treatment options are limited, there is a critical need for better understanding the pathogenesis and identifying risk factors that might be used in primary prevention. We have recently completed the field work for a 3-year case-control study at three hospitals in Ghana, Korle Bu Teaching Hospital in Accra and Komfo Anoyke Teaching Hospital and Peace and Love Hospital in Kumasi. The main aims of this study were to perform careful pathologic classification of breast tumors in order to relate a variety of risk factors to distinctive tumor subtypes. As eligible cases, we included women 18-74 years of age who were diagnosed and/or treated for incident breast cancer at study hospitals. Population controls were identified through household sampling, based on data provided by the 2010 Ghanaian census. Both case and control subjects were interviewed, had anthropometric measurements taken, and asked to provide blood, saliva and fecal specimens. Breast tissue samples were acquired from the breast cancer cases. We successfully recruited approximately 2,220 cases and an equal number of controls. Response rates to the interview were exceptionally high (92-99%) and biologic samples were obtained from most of the interviewed subjects. The collected data are currently being cleaned and analyses will be forthcoming. |